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    Prion protein can exist in multiple conformations, called isoforms. PrPc, the normally occuring isoform, is quite predominant in the nervous system and other parts of the body. PrPsc, an abnormal isoform, causes disease by forcing the misfolding of PrPc isoform proteins, and forming plaques in the central nervous system. This results in neurodegenerative diseases such as scrapie, bovine spongiform encephalopathy (also called Mad Cow Disease), Creutzfeldt-Jakob Disease, and others.

    Depicted in this painting are the protein structures of both the healthy prion isoform (PrPc) and the misfolded, pathogenic isoform (PrPsc).

    This acrylic painting is 12" x 12" and 5/8" thick on stretched canvas.

    Prion Protein Structures